Subcutaneous injection of Vitamin K1 is the preferred parenteral route of administration because intravenous Vitamin K1 can cause anaphylaxis, and hematomas may form at intramuscular sites. In order to prevent relapse, continue therapy for 6 weeks. Taper the maintenance dose by one-half every 2 weeks during treatment.
Warfarin is a relatively short-acting rodenticide, and treatment for a total of 1 week usually is adequate. Other vitamin K deficient states include: biliary obstruction, intrahepatic cholestasis, intestinal malabsorption and chronic oral antibiotic administration. It is often initiated pending test results, but maintenance of vitamin K is not indicated for patients having diagnoses of thrombocytopenia, hereditary factor deficiencies, or DIC.
Neil Long Dr Neil Long BMBS FACEM FRCEM FRCPC.Įmergency Physician at Burnaby Hospital in Vancouver. RELATED: Zinc Element Symbol Toxicology Library No adverse events or bleeding complications were observed. This prospective cohort study was designed to address whether 1 mg of oral vitamin K effectively reduces the INR value of such patients. The most appropriate management strategy in these patients is unknown. Ffp may be administered instead of PCC or rFVIIa if those therapies are unavailable. For soft tissue bleeding, 100 units/kg every 12 hours is recommended.įor severe hemorrhage (eg, central nervous system bleeding), 100 units/kg every 12 hours is recommended, although a more frequent dosing interval (ie, 6 h) may be indicated until clear clinical improvement is achieved. The lower range is recommended for joint or mucous membrane bleeding. Mplex concentrate (PCC), as a general guideline, a dosage of 50-100 units/kg IV at 12-hour intervals is recommended. In this article we will be discussing a very common question: vitamin k antidote.
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